Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses
Identifieur interne : 003554 ( Main/Exploration ); précédent : 003553; suivant : 003555Vaccination of mice with recombinant baculovirus expressing spike or nucleocapsid protein of SARS-like coronavirus generates humoral and cellular immune responses
Auteurs : Bingke Bai [République populaire de Chine] ; Xinya Lu [République populaire de Chine] ; Jin Meng [République populaire de Chine] ; Qinxue Hu [République populaire de Chine] ; Panyong Mao [République populaire de Chine] ; Baojing Lu [République populaire de Chine] ; Ze Chen [République populaire de Chine] ; Zhiming Yuan [République populaire de Chine] ; Hanzhong Wang [République populaire de Chine]Source :
- Molecular Immunology [ 0161-5890 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Baculoviridae (génétique), Baculoviridae (immunologie), Cricetinae, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (biosynthèse), Glycoprotéines membranaires (génétique), Immunité cellulaire, Interféron gamma (immunologie), Interleukine-4 (immunologie), Lignée cellulaire, Lymphocytes T CD4+ (immunologie), Production d'anticorps, Protéines de l'enveloppe virale (biosynthèse), Protéines de l'enveloppe virale (génétique), Protéines nucléocapside (biosynthèse), Protéines nucléocapside (génétique), Régions promotrices (génétique), Souris, Souris de lignée BALB C, Vaccination, Virus du SRAS (immunologie), Virus du SRAS (métabolisme).
- MESH :
- biosynthèse : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines nucléocapside.
- génétique : Baculoviridae, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Protéines nucléocapside.
- immunologie : Baculoviridae, Interféron gamma, Interleukine-4, Lymphocytes T CD4+, Virus du SRAS.
- métabolisme : Virus du SRAS.
- Animaux, Cricetinae, Glycoprotéine de spicule des coronavirus, Immunité cellulaire, Lignée cellulaire, Production d'anticorps, Régions promotrices (génétique), Souris, Souris de lignée BALB C, Vaccination.
English descriptors
- KwdEn :
- Animals, Antibody Formation, Baculoviridae (genetics), Baculoviridae (immunology), CD4-Positive T-Lymphocytes (immunology), Cell Line, Cricetinae, Immunity, Cellular, Interferon-gamma (immunology), Interleukin-4 (immunology), Membrane Glycoproteins (biosynthesis), Membrane Glycoproteins (genetics), Mice, Mice, Inbred BALB C, Nucleocapsid Proteins (biosynthesis), Nucleocapsid Proteins (genetics), Promoter Regions, Genetic, SARS Virus (immunology), SARS Virus (metabolism), Spike Glycoprotein, Coronavirus, Vaccination, Viral Envelope Proteins (biosynthesis), Viral Envelope Proteins (genetics).
- MESH :
- chemical , biosynthesis : Membrane Glycoproteins, Nucleocapsid Proteins, Viral Envelope Proteins.
- chemical , genetics : Membrane Glycoproteins, Nucleocapsid Proteins, Viral Envelope Proteins.
- chemical , immunology : Interferon-gamma, Interleukin-4.
- genetics : Baculoviridae.
- immunology : Baculoviridae, CD4-Positive T-Lymphocytes, SARS Virus.
- metabolism : SARS Virus.
- Animals, Antibody Formation, Cell Line, Cricetinae, Immunity, Cellular, Mice, Mice, Inbred BALB C, Promoter Regions, Genetic, Spike Glycoprotein, Coronavirus, Vaccination.
Abstract
Continuous efforts have been made to develop a prophylactic vaccine against severe acute respiratory syndrome coronavirus (SARS-CoV). In this study, two recombinant baculoviruses, vAc-N and vAc-S, were constructed, which contained the mammalian-cell activate promoter element, human elongation factor 1α-subunit (EF-1α), the human cytomegalovirus (CMV) immediate-early promoter, and the nucleocapsid (N) or spike (S) gene of bat SARS-like CoV (SL-CoV) under the control of the CMV promoter. Mice were subcutaneously and intraperitoneally injected with recombinant baculovirus, and both humoral and cellular immune responses were induced in the vaccinated groups. The secretion level of IFN-γ was much higher than that of IL-4 in vAc-N or vAc-S immunized groups, suggesting a strong Th1 bias towards cellular immune responses. Additionally, a marked increase of CD4 T cell immune responses and high levels of anti-SARS-CoV humoral responses were also detected in the vAc-N or vAc-S immunized groups. In contrast, there were significantly weaker cellular immune responses, as well as less antibody production than in the control groups. Our data demonstrates that the recombinant baculovirus can serve as an effective vaccine strategy. In addition, because effective SARS vaccines should act to not only prevent the reemergence of SARS-CoV, but also to provide cross-protection against SL-CoV, findings in this study may have implications for developing such cross-protective vaccines.
Url:
DOI: 10.1016/j.molimm.2007.08.010
PubMed: 17905435
PubMed Central: 7112626
Affiliations:
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id="aff1">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of the Chinese Academy of Sciences, Beijing 100049, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of the Chinese Academy of Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lu, Xinya" sort="Lu, Xinya" uniqKey="Lu X" first="Xinya" last="Lu">Xinya Lu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Virology, Wuhan Institute 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Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of the Chinese Academy of Sciences, Beijing 100049, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of the Chinese Academy of Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Hu, Qinxue" sort="Hu, Qinxue" uniqKey="Hu Q" first="Qinxue" last="Hu">Qinxue Hu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing 100039, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Virology, Institute of Infectious Disease, 302 Hospital, Beijing 100039</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Lu, Baojing" sort="Lu, Baojing" uniqKey="Lu B" first="Baojing" last="Lu">Baojing Lu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Graduate School of the Chinese Academy of Sciences, Beijing 100049, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Graduate School of the Chinese Academy of Sciences, Beijing 100049</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Yuan, Zhiming" sort="Yuan, Zhiming" uniqKey="Yuan Z" first="Zhiming" last="Yuan">Zhiming Yuan</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei, PR China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071 Hubei</wicri:regionArea><wicri:noRegion>430071 Hubei</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Immunology</title><idno type="ISSN">0161-5890</idno><idno type="eISSN">1872-9142</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Baculoviridae (genetics)</term><term>Baculoviridae (immunology)</term><term>CD4-Positive T-Lymphocytes (immunology)</term><term>Cell Line</term><term>Cricetinae</term><term>Immunity, Cellular</term><term>Interferon-gamma (immunology)</term><term>Interleukin-4 (immunology)</term><term>Membrane Glycoproteins (biosynthesis)</term><term>Membrane Glycoproteins (genetics)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Nucleocapsid Proteins (biosynthesis)</term><term>Nucleocapsid Proteins (genetics)</term><term>Promoter Regions, Genetic</term><term>SARS Virus (immunology)</term><term>SARS Virus (metabolism)</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccination</term><term>Viral Envelope Proteins (biosynthesis)</term><term>Viral Envelope Proteins (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Baculoviridae (génétique)</term><term>Baculoviridae (immunologie)</term><term>Cricetinae</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (biosynthèse)</term><term>Glycoprotéines membranaires (génétique)</term><term>Immunité cellulaire</term><term>Interféron gamma (immunologie)</term><term>Interleukine-4 (immunologie)</term><term>Lignée cellulaire</term><term>Lymphocytes T CD4+ (immunologie)</term><term>Production d'anticorps</term><term>Protéines de l'enveloppe virale (biosynthèse)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines nucléocapside (biosynthèse)</term><term>Protéines nucléocapside (génétique)</term><term>Régions promotrices (génétique)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccination</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Membrane Glycoproteins</term><term>Nucleocapsid Proteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Nucleocapsid Proteins</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferon-gamma</term><term>Interleukin-4</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Baculoviridae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Baculoviridae</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Protéines nucléocapside</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Baculoviridae</term><term>Interféron gamma</term><term>Interleukine-4</term><term>Lymphocytes T CD4+</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Baculoviridae</term><term>CD4-Positive T-Lymphocytes</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Cell Line</term><term>Cricetinae</term><term>Immunity, Cellular</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Promoter Regions, Genetic</term><term>Spike Glycoprotein, Coronavirus</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cricetinae</term><term>Glycoprotéine de spicule des coronavirus</term><term>Immunité cellulaire</term><term>Lignée cellulaire</term><term>Production d'anticorps</term><term>Régions promotrices (génétique)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Continuous efforts have been made to develop a prophylactic vaccine against severe acute respiratory syndrome coronavirus (SARS-CoV). In this study, two recombinant baculoviruses, vAc-N and vAc-S, were constructed, which contained the mammalian-cell activate promoter element, human elongation factor 1α-subunit (EF-1α), the human cytomegalovirus (CMV) immediate-early promoter, and the nucleocapsid (N) or spike (S) gene of bat SARS-like CoV (SL-CoV) under the control of the CMV promoter. Mice were subcutaneously and intraperitoneally injected with recombinant baculovirus, and both humoral and cellular immune responses were induced in the vaccinated groups. The secretion level of IFN-γ was much higher than that of IL-4 in vAc-N or vAc-S immunized groups, suggesting a strong Th1 bias towards cellular immune responses. Additionally, a marked increase of CD4 T cell immune responses and high levels of anti-SARS-CoV humoral responses were also detected in the vAc-N or vAc-S immunized groups. In contrast, there were significantly weaker cellular immune responses, as well as less antibody production than in the control groups. Our data demonstrates that the recombinant baculovirus can serve as an effective vaccine strategy. In addition, because effective SARS vaccines should act to not only prevent the reemergence of SARS-CoV, but also to provide cross-protection against SL-CoV, findings in this study may have implications for developing such cross-protective vaccines.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Anton, I M" uniqKey="Anton I">I.M. Anton</name></author><author><name sortKey="Gonzalez, S" uniqKey="Gonzalez S">S. Gonzalez</name></author><author><name sortKey="Bullido, M J" uniqKey="Bullido M">M.J. Bullido</name></author><author><name sortKey="Corsin, M" uniqKey="Corsin M">M. Corsin</name></author><author><name sortKey="Risco, C" uniqKey="Risco C">C. Risco</name></author><author><name sortKey="Langeveld, J P" uniqKey="Langeveld J">J.P. Langeveld</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L. Enjuanes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bisht, H" uniqKey="Bisht H">H. Bisht</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Vogel, L" uniqKey="Vogel L">L. Vogel</name></author><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A. Bukreyev</name></author><author><name sortKey="Collins, P L" uniqKey="Collins P">P.L. Collins</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Moss, B" uniqKey="Moss B">B. Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bottomly, K" uniqKey="Bottomly K">K. Bottomly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourgeois, C" uniqKey="Bourgeois C">C. Bourgeois</name></author><author><name sortKey="Rocha, B" uniqKey="Rocha B">B. Rocha</name></author><author><name sortKey="Tanchot, C" uniqKey="Tanchot C">C. Tanchot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourgeois, C" uniqKey="Bourgeois C">C. Bourgeois</name></author><author><name sortKey="Veiga Fernandes, H" uniqKey="Veiga Fernandes H">H. Veiga-Fernandes</name></author><author><name sortKey="Joret, A M" uniqKey="Joret A">A.M. Joret</name></author><author><name sortKey="Rocha, B" uniqKey="Rocha B">B. Rocha</name></author><author><name sortKey="Tanchot, C" uniqKey="Tanchot C">C. Tanchot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boyce, F M" uniqKey="Boyce F">F.M. Boyce</name></author><author><name sortKey="Bucher, N L" uniqKey="Bucher N">N.L. Bucher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bukreyev, A" uniqKey="Bukreyev A">A. Bukreyev</name></author><author><name sortKey="Lamirande, E W" uniqKey="Lamirande E">E.W. Lamirande</name></author><author><name sortKey="Buchholz, U J" uniqKey="Buchholz U">U.J. Buchholz</name></author><author><name sortKey="Vogel, L N" uniqKey="Vogel L">L.N. Vogel</name></author><author><name sortKey="Elkins, W R" uniqKey="Elkins W">W.R. Elkins</name></author><author><name sortKey="St Claire, M" uniqKey="St Claire M">M. St Claire</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Collins, P L" uniqKey="Collins P">P.L. Collins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carbonell, L F" uniqKey="Carbonell L">L.F. Carbonell</name></author><author><name sortKey="Klowden, M J" uniqKey="Klowden M">M.J. Klowden</name></author><author><name sortKey="Miller, L K" uniqKey="Miller L">L.K. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cavanagh, D" uniqKey="Cavanagh D">D. Cavanagh</name></author><author><name sortKey="Davis, P J" uniqKey="Davis P">P.J. Davis</name></author><author><name sortKey="Darbyshire, J H" uniqKey="Darbyshire J">J.H. Darbyshire</name></author><author><name sortKey="Peters, R W" uniqKey="Peters R">R.W. Peters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name></author><author><name sortKey="Pei, D" uniqKey="Pei D">D. Pei</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L. Jiang</name></author><author><name sortKey="Song, Y" uniqKey="Song Y">Y. Song</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Zhou, D" uniqKey="Zhou D">D. Zhou</name></author><author><name sortKey="Zhai, J" uniqKey="Zhai J">J. Zhai</name></author><author><name sortKey="Du, Z" uniqKey="Du Z">Z. Du</name></author><author><name sortKey="Li, B" uniqKey="Li B">B. Li</name></author><author><name sortKey="Qiu, M" uniqKey="Qiu M">M. Qiu</name></author><author><name sortKey="Han, Y" uniqKey="Han Y">Y. Han</name></author><author><name sortKey="Guo, Z" uniqKey="Guo Z">Z. Guo</name></author><author><name sortKey="Yang, R" uniqKey="Yang R">R. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, T" uniqKey="Cheng T">T. Cheng</name></author><author><name sortKey="Xu, C Y" uniqKey="Xu C">C.Y. Xu</name></author><author><name sortKey="Wang, Y B" uniqKey="Wang Y">Y.B. Wang</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M. Chen</name></author><author><name sortKey="Wu, T" uniqKey="Wu T">T. Wu</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Xia, N S" uniqKey="Xia N">N.S. Xia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheshenko, N" uniqKey="Cheshenko N">N. Cheshenko</name></author><author><name sortKey="Krougliak, N" uniqKey="Krougliak N">N. Krougliak</name></author><author><name sortKey="Eisensmith, R C" uniqKey="Eisensmith R">R.C. Eisensmith</name></author><author><name sortKey="Krougliak, V A" uniqKey="Krougliak V">V.A. Krougliak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Condreay, J P" uniqKey="Condreay J">J.P. Condreay</name></author><author><name sortKey="Witherspoon, S M" uniqKey="Witherspoon S">S.M. Witherspoon</name></author><author><name sortKey="Clay, W C" uniqKey="Clay W">W.C. Clay</name></author><author><name sortKey="Kost, T A" uniqKey="Kost T">T.A. Kost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delaney, W E" uniqKey="Delaney W">W.E. Delaney</name></author><author><name sortKey="Isom, H C" uniqKey="Isom H">H.C. Isom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Rabenau, H" uniqKey="Rabenau H">H. Rabenau</name></author><author><name sortKey="Panning, M" uniqKey="Panning M">M. Panning</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L. Kolesnikova</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Berger, A" uniqKey="Berger A">A. Berger</name></author><author><name sortKey="Burguiere, A M" uniqKey="Burguiere A">A.M. Burguière</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Escriou, N" uniqKey="Escriou N">N. Escriou</name></author><author><name sortKey="Grywna, K" uniqKey="Grywna K">K. Grywna</name></author><author><name sortKey="Kramme, S" uniqKey="Kramme S">S. Kramme</name></author><author><name sortKey="Manuguerra, J C" uniqKey="Manuguerra J">J.C. Manuguerra</name></author><author><name sortKey="Muller, S" uniqKey="Muller S">S. Müller</name></author><author><name sortKey="Rickerts, V" uniqKey="Rickerts V">V. Rickerts</name></author><author><name sortKey="Sturmer, M" uniqKey="Sturmer M">M. Stürmer</name></author><author><name sortKey="Vieth, S" uniqKey="Vieth S">S. Vieth</name></author><author><name sortKey="Klenk, H D" uniqKey="Klenk H">H.D. Klenk</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duisit, G" uniqKey="Duisit G">G. Duisit</name></author><author><name sortKey="Saleun, S" uniqKey="Saleun S">S. Saleun</name></author><author><name sortKey="Douthe, S" uniqKey="Douthe S">S. Douthe</name></author><author><name sortKey="Barsoum, J" uniqKey="Barsoum J">J. Barsoum</name></author><author><name sortKey="Chadeuf, G" uniqKey="Chadeuf G">G. Chadeuf</name></author><author><name sortKey="Moullier, P" uniqKey="Moullier P">P. Moullier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T. Kuiken</name></author><author><name sortKey="Schutten, M" uniqKey="Schutten M">M. Schutten</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G. van Amerongen</name></author><author><name sortKey="Van Doornum, G J" uniqKey="Van Doornum G">G.J. van Doornum</name></author><author><name sortKey="Van Den Hoogen, B G" uniqKey="Van Den Hoogen B">B.G. van den Hoogen</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M. Peiris</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Stohr, K" uniqKey="Stohr K">K. Stöhr</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, W" uniqKey="Gao W">W. Gao</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A. Tamin</name></author><author><name sortKey="Soloff, A" uniqKey="Soloff A">A. Soloff</name></author><author><name sortKey="D Iuto, L" uniqKey="D Iuto L">L. D’Aiuto</name></author><author><name sortKey="Nwanegbo, E" uniqKey="Nwanegbo E">E. Nwanegbo</name></author><author><name sortKey="Robbins, P D" uniqKey="Robbins P">P.D. Robbins</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Barratt Boyes, S" uniqKey="Barratt Boyes S">S. Barratt-Boyes</name></author><author><name sortKey="Gambotto, A" uniqKey="Gambotto A">A. Gambotto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, M" uniqKey="Guan M">M. Guan</name></author><author><name sortKey="Chen, H Y" uniqKey="Chen H">H.Y. Chen</name></author><author><name sortKey="Foo, S Y" uniqKey="Foo S">S.Y. Foo</name></author><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name></author><author><name sortKey="Goh, P Y" uniqKey="Goh P">P.Y. Goh</name></author><author><name sortKey="Wee, S H" uniqKey="Wee S">S.H. Wee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name></author><author><name sortKey="Siddiqui, P" uniqKey="Siddiqui P">P. Siddiqui</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, H" uniqKey="He H">H. He</name></author><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y. Tang</name></author><author><name sortKey="Qin, X" uniqKey="Qin X">X. Qin</name></author><author><name sortKey="Xu, W" uniqKey="Xu W">W. Xu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X. Liu</name></author><author><name sortKey="Xiong, S" uniqKey="Xiong S">S. Xiong</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Zhang, M" uniqKey="Zhang M">M. Zhang</name></author><author><name sortKey="Duan, M" uniqKey="Duan M">M. Duan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmann, C" uniqKey="Hofmann C">C. Hofmann</name></author><author><name sortKey="Sandig, V" uniqKey="Sandig V">V. Sandig</name></author><author><name sortKey="Jennings, G" uniqKey="Jennings G">G. Jennings</name></author><author><name sortKey="Rudolph, M" uniqKey="Rudolph M">M. Rudolph</name></author><author><name sortKey="Schlag, P" uniqKey="Schlag P">P. Schlag</name></author><author><name sortKey="Strauss, M" uniqKey="Strauss M">M. Strauss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, L H" uniqKey="Hou L">L.H. Hou</name></author><author><name sortKey="Du, G X" uniqKey="Du G">G.X. Du</name></author><author><name sortKey="Guan, R B" uniqKey="Guan R">R.B. Guan</name></author><author><name sortKey="Tong, Y G" uniqKey="Tong Y">Y.G. Tong</name></author><author><name sortKey="Wang, H T" uniqKey="Wang H">H.T. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, L R" uniqKey="Huang L">L.R. Huang</name></author><author><name sortKey="Chiu, C M" uniqKey="Chiu C">C.M. Chiu</name></author><author><name sortKey="Yeh, S H" uniqKey="Yeh S">S.H. Yeh</name></author><author><name sortKey="Huang, W H" uniqKey="Huang W">W.H. Huang</name></author><author><name sortKey="Hsueh, P R" uniqKey="Hsueh P">P.R. Hsueh</name></author><author><name sortKey="Yang, W Z" uniqKey="Yang W">W.Z. Yang</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Su, I J" uniqKey="Su I">I.J. Su</name></author><author><name sortKey="Chang, S C" uniqKey="Chang S">S.C. Chang</name></author><author><name sortKey="Chen, P J" uniqKey="Chen P">P.J. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author><author><name sortKey="Ma, R" uniqKey="Ma R">R. Ma</name></author><author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. Jackwood</name></author><author><name sortKey="Hilt, D A" uniqKey="Hilt D">D.A. Hilt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jones, I" uniqKey="Jones I">I. Jones</name></author><author><name sortKey="Morikawa, Y" uniqKey="Morikawa Y">Y. Morikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kapczynski, D R" uniqKey="Kapczynski D">D.R. Kapczynski</name></author><author><name sortKey="Hilt, D A" uniqKey="Hilt D">D.A. Hilt</name></author><author><name sortKey="Shapiro, D" uniqKey="Shapiro D">D. Shapiro</name></author><author><name sortKey="Sellers, H S" uniqKey="Sellers H">H.S. Sellers</name></author><author><name sortKey="Jackwood, M W" uniqKey="Jackwood M">M.W. Jackwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L. Xu</name></author><author><name sortKey="Stadler, K" uniqKey="Stadler K">K. Stadler</name></author><author><name sortKey="Ulmer, J B" uniqKey="Ulmer J">J.B. Ulmer</name></author><author><name sortKey="Abrignani, S" uniqKey="Abrignani S">S. Abrignani</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R. Rappuoli</name></author><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kost, T A" uniqKey="Kost T">T.A. Kost</name></author><author><name sortKey="Condreay, J P" uniqKey="Condreay J">J.P. Condreay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D. Erdman</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C. Urbani</name></author><author><name sortKey="Comer, J A" uniqKey="Comer J">J.A. Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Rollin, P E" uniqKey="Rollin P">P.E. Rollin</name></author><author><name sortKey="Dowell, S F" uniqKey="Dowell S">S.F. Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A.E. Ling</name></author><author><name sortKey="Humphrey, C D" uniqKey="Humphrey C">C.D. Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W.J. Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J. Guarner</name></author><author><name sortKey="Paddock, C D" uniqKey="Paddock C">C.D. Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P. Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B. Fields</name></author><author><name sortKey="Derisi, J" uniqKey="Derisi J">J. DeRisi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J.Y. Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N. Cox</name></author><author><name sortKey="Hughes, J M" uniqKey="Hughes J">J.M. Hughes</name></author><author><name sortKey="Leduc, J W" uniqKey="Leduc J">J.W. LeDuc</name></author><author><name sortKey="Bellini, W J" uniqKey="Bellini W">W.J. Bellini</name></author><author><name sortKey="Anderson, L J" uniqKey="Anderson L">L.J. Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Li, K S" uniqKey="Li K">K.S. Li</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Tsoi, H W" uniqKey="Tsoi H">H.W. Tsoi</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B.H. Wong</name></author><author><name sortKey="Wong, S S" uniqKey="Wong S">S.S. Wong</name></author><author><name sortKey="Leung, S Y" uniqKey="Leung S">S.Y. Leung</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, D T" uniqKey="Leung D">D.T. Leung</name></author><author><name sortKey="Tam, F C" uniqKey="Tam F">F.C. Tam</name></author><author><name sortKey="Ma, C H" uniqKey="Ma C">C.H. Ma</name></author><author><name sortKey="Chan, P K" uniqKey="Chan P">P.K. Chan</name></author><author><name sortKey="Cheung, J L" uniqKey="Cheung J">J.L. Cheung</name></author><author><name sortKey="Niu, H" uniqKey="Niu H">H. Niu</name></author><author><name sortKey="Tam, J S" uniqKey="Tam J">J.S. Tam</name></author><author><name sortKey="Lim, P L" uniqKey="Lim P">P.L. Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, B" uniqKey="Li B">B. Li</name></author><author><name sortKey="Wu, H Y" uniqKey="Wu H">H.Y. Wu</name></author><author><name sortKey="Qian, X P" uniqKey="Qian X">X.P. Qian</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Chen, W F" uniqKey="Chen W">W.F. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name></author><author><name sortKey="Ren, W" uniqKey="Ren W">W. Ren</name></author><author><name sortKey="Smith, C" uniqKey="Smith C">C. Smith</name></author><author><name sortKey="Epstein, J H" uniqKey="Epstein J">J.H. Epstein</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Crameri, G" uniqKey="Crameri G">G. Crameri</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z. Hu</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H. Zhang</name></author><author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name></author><author><name sortKey="Mceachern, J" uniqKey="Mceachern J">J. McEachern</name></author><author><name sortKey="Field, H" uniqKey="Field H">H. Field</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P. Daszak</name></author><author><name sortKey="Eaton, B T" uniqKey="Eaton B">B.T. Eaton</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Wang, L F" uniqKey="Wang L">L.F. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luckow, V A" uniqKey="Luckow V">V.A. Luckow</name></author><author><name sortKey="Summers, M D" uniqKey="Summers M">M.D. Summers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, L K" uniqKey="Miller L">L.K. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mosmann, T R" uniqKey="Mosmann T">T.R. Mosmann</name></author><author><name sortKey="Cofman, R L" uniqKey="Cofman R">R.L. Cofman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakhai, B" uniqKey="Nakhai B">B. Nakhai</name></author><author><name sortKey="Pal, R" uniqKey="Pal R">R. Pal</name></author><author><name sortKey="Sridhar, P" uniqKey="Sridhar P">P. Sridhar</name></author><author><name sortKey="Talwar, G P" uniqKey="Talwar G">G.P. Talwar</name></author><author><name sortKey="Hasnain, S E" uniqKey="Hasnain S">S.E. Hasnain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ojala, K" uniqKey="Ojala K">K. Ojala</name></author><author><name sortKey="Mottershead, D G" uniqKey="Mottershead D">D.G. Mottershead</name></author><author><name sortKey="Suokko, A" uniqKey="Suokko A">A. Suokko</name></author><author><name sortKey="Oker Blom, C" uniqKey="Oker Blom C">C. Oker-Blom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okada, M" uniqKey="Okada M">M. Okada</name></author><author><name sortKey="Takemoto, Y" uniqKey="Takemoto Y">Y. Takemoto</name></author><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y. Okuno</name></author><author><name sortKey="Hashimoto, S" uniqKey="Hashimoto S">S. Hashimoto</name></author><author><name sortKey="Yoshida, S" uniqKey="Yoshida S">S. Yoshida</name></author><author><name sortKey="Fukunaga, Y" uniqKey="Fukunaga Y">Y. Fukunaga</name></author><author><name sortKey="Tanaka, T" uniqKey="Tanaka T">T. Tanaka</name></author><author><name sortKey="Kita, Y" uniqKey="Kita Y">Y. Kita</name></author><author><name sortKey="Kuwayama, S" uniqKey="Kuwayama S">S. Kuwayama</name></author><author><name sortKey="Muraki, Y" uniqKey="Muraki Y">Y. Muraki</name></author><author><name sortKey="Kanamaru, N" uniqKey="Kanamaru N">N. Kanamaru</name></author><author><name sortKey="Takai, H" uniqKey="Takai H">H. Takai</name></author><author><name sortKey="Okada, C" uniqKey="Okada C">C. Okada</name></author><author><name sortKey="Sakaguchi, Y" uniqKey="Sakaguchi Y">Y. Sakaguchi</name></author><author><name sortKey="Furukawa, I" uniqKey="Furukawa I">I. Furukawa</name></author><author><name sortKey="Yamada, K" uniqKey="Yamada K">K. Yamada</name></author><author><name sortKey="Matsumoto, M" uniqKey="Matsumoto M">M. Matsumoto</name></author><author><name sortKey="Kase, T" uniqKey="Kase T">T. Kase</name></author><author><name sortKey="Demello, D E" uniqKey="Demello D">D.E. Demello</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Chen, P J" uniqKey="Chen P">P.J. Chen</name></author><author><name sortKey="Yamamoto, N" uniqKey="Yamamoto N">N. Yamamoto</name></author><author><name sortKey="Yoshinaka, Y" uniqKey="Yoshinaka Y">Y. Yoshinaka</name></author><author><name sortKey="Nomura, T" uniqKey="Nomura T">T. Nomura</name></author><author><name sortKey="Ishida, I" uniqKey="Ishida I">I. Ishida</name></author><author><name sortKey="Morikawa, S" uniqKey="Morikawa S">S. Morikawa</name></author><author><name sortKey="Tashiro, M" uniqKey="Tashiro M">M. Tashiro</name></author><author><name sortKey="Sakatani, M" uniqKey="Sakatani M">M. Sakatani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y. Guan</name></author><author><name sortKey="Yam, L Y" uniqKey="Yam L">L.Y. Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W. Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J. Nicholls</name></author><author><name sortKey="Yee, W K" uniqKey="Yee W">W.K. Yee</name></author><author><name sortKey="Yan, W W" uniqKey="Yan W">W.W. Yan</name></author><author><name sortKey="Cheung, M T" uniqKey="Cheung M">M.T. Cheung</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tsang, D N" uniqKey="Tsang D">D.N. Tsang</name></author><author><name sortKey="Yung, R W" uniqKey="Yung R">R.W. Yung</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T.K. Ng</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieroni, L" uniqKey="Pieroni L">L. Pieroni</name></author><author><name sortKey="Maione, D" uniqKey="Maione D">D. Maione</name></author><author><name sortKey="La Monica, N" uniqKey="La Monica N">N. La Monica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poutanen, S M" uniqKey="Poutanen S">S.M. Poutanen</name></author><author><name sortKey="Low, D E" uniqKey="Low D">D.E. Low</name></author><author><name sortKey="Henry, B" uniqKey="Henry B">B. Henry</name></author><author><name sortKey="Finkelstein, S" uniqKey="Finkelstein S">S. Finkelstein</name></author><author><name sortKey="Rose, D" uniqKey="Rose D">D. Rose</name></author><author><name sortKey="Green, K" uniqKey="Green K">K. Green</name></author><author><name sortKey="Tellier, R" uniqKey="Tellier R">R. Tellier</name></author><author><name sortKey="Draker, R" uniqKey="Draker R">R. Draker</name></author><author><name sortKey="Adachi, D" uniqKey="Adachi D">D. Adachi</name></author><author><name sortKey="Ayers, M" uniqKey="Ayers M">M. Ayers</name></author><author><name sortKey="Chan, A K" uniqKey="Chan A">A.K. Chan</name></author><author><name sortKey="Skowronski, D M" uniqKey="Skowronski D">D.M. Skowronski</name></author><author><name sortKey="Salit, I" uniqKey="Salit I">I. Salit</name></author><author><name sortKey="Simor, A E" uniqKey="Simor A">A.E. Simor</name></author><author><name sortKey="Slutsky, A S" uniqKey="Slutsky A">A.S. Slutsky</name></author><author><name sortKey="Doyle, P W" uniqKey="Doyle P">P.W. Doyle</name></author><author><name sortKey="Krajden, M" uniqKey="Krajden M">M. Krajden</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M. Petric</name></author><author><name sortKey="Brunham, R C" uniqKey="Brunham R">R.C. Brunham</name></author><author><name sortKey="Mcgeer, A J" uniqKey="Mcgeer A">A.J. McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powers, G D" uniqKey="Powers G">G.D. Powers</name></author><author><name sortKey="Abbas, A K" uniqKey="Abbas A">A.K. Abbas</name></author><author><name sortKey="Miller, R A" uniqKey="Miller R">R.A. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, H" uniqKey="Ren H">H. Ren</name></author><author><name sortKey="Zhu, F L" uniqKey="Zhu F">F.L. Zhu</name></author><author><name sortKey="Zhu, S Y" uniqKey="Zhu S">S.Y. Zhu</name></author><author><name sortKey="Song, Y" uniqKey="Song Y">Y. Song</name></author><author><name sortKey="Qi, Z T" uniqKey="Qi Z">Z.T. Qi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W. Ren</name></author><author><name sortKey="Li, W" uniqKey="Li W">W. Li</name></author><author><name sortKey="Yu, M" uniqKey="Yu M">M. Yu</name></author><author><name sortKey="Hao, P" uniqKey="Hao P">P. Hao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Zhou, P" uniqKey="Zhou P">P. Zhou</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G. Zhao</name></author><author><name sortKey="Zhong, Y" uniqKey="Zhong Y">Y. Zhong</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Wang, L F" uniqKey="Wang L">L.F. Wang</name></author><author><name sortKey="Shi, Z" uniqKey="Shi Z">Z. Shi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sestak, K" uniqKey="Sestak K">K. Sestak</name></author><author><name sortKey="Meister, R K" uniqKey="Meister R">R.K. Meister</name></author><author><name sortKey="Hayes, J R" uniqKey="Hayes J">J.R. Hayes</name></author><author><name sortKey="Kim, L" uniqKey="Kim L">L. Kim</name></author><author><name sortKey="Lewis, P A" uniqKey="Lewis P">P.A. Lewis</name></author><author><name sortKey="Myers, G" uniqKey="Myers G">G. Myers</name></author><author><name sortKey="Saif, L J" uniqKey="Saif L">L.J. Saif</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shoji, I" uniqKey="Shoji I">I. Shoji</name></author><author><name sortKey="Aizaki, H" uniqKey="Aizaki H">H. Aizaki</name></author><author><name sortKey="Tani, H" uniqKey="Tani H">H. Tani</name></author><author><name sortKey="Ishii, K" uniqKey="Ishii K">K. Ishii</name></author><author><name sortKey="Chiba, T" uniqKey="Chiba T">T. Chiba</name></author><author><name sortKey="Saito, I" uniqKey="Saito I">I. Saito</name></author><author><name sortKey="Miyamura, T" uniqKey="Miyamura T">T. Miyamura</name></author><author><name sortKey="Matsuura, Y" uniqKey="Matsuura Y">Y. Matsuura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, C S" uniqKey="Song C">C.S. Song</name></author><author><name sortKey="Lee, Y J" uniqKey="Lee Y">Y.J. Lee</name></author><author><name sortKey="Lee, C W" uniqKey="Lee C">C.W. Lee</name></author><author><name sortKey="Sung, H W" uniqKey="Sung H">H.W. Sung</name></author><author><name sortKey="Kim, J H" uniqKey="Kim J">J.H. Kim</name></author><author><name sortKey="Mo, I P" uniqKey="Mo I">I.P. Mo</name></author><author><name sortKey="Izumiya, Y" uniqKey="Izumiya Y">Y. Izumiya</name></author><author><name sortKey="Jang, H K" uniqKey="Jang H">H.K. Jang</name></author><author><name sortKey="Mikami, T" uniqKey="Mikami T">T. Mikami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, S U" uniqKey="Song S">S.U. Song</name></author><author><name sortKey="Shin, S H" uniqKey="Shin S">S.H. Shin</name></author><author><name sortKey="Kim, S K" uniqKey="Kim S">S.K. Kim</name></author><author><name sortKey="Choi, G S" uniqKey="Choi G">G.S. Choi</name></author><author><name sortKey="Kim, W C" uniqKey="Kim W">W.C. Kim</name></author><author><name sortKey="Lee, M H" uniqKey="Lee M">M.H. Lee</name></author><author><name sortKey="Kim, S J" uniqKey="Kim S">S.J. Kim</name></author><author><name sortKey="Kim, I H" uniqKey="Kim I">I.H. Kim</name></author><author><name sortKey="Choi, M S" uniqKey="Choi M">M.S. Choi</name></author><author><name sortKey="Hong, Y J" uniqKey="Hong Y">Y.J. Hong</name></author><author><name sortKey="Lee, K H" uniqKey="Lee K">K.H. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spruth, M" uniqKey="Spruth M">M. Spruth</name></author><author><name sortKey="Kistner, O" uniqKey="Kistner O">O. Kistner</name></author><author><name sortKey="Savidis Dacho, H" uniqKey="Savidis Dacho H">H. Savidis-Dacho</name></author><author><name sortKey="Hitter, E" uniqKey="Hitter E">E. Hitter</name></author><author><name sortKey="Crowe, B" uniqKey="Crowe B">B. Crowe</name></author><author><name sortKey="Gerencer, M" uniqKey="Gerencer M">M. Gerencer</name></author><author><name sortKey="Bruhl, P" uniqKey="Bruhl P">P. Bruhl</name></author><author><name sortKey="Grillberger, L" uniqKey="Grillberger L">L. Grillberger</name></author><author><name sortKey="Reiter, M" uniqKey="Reiter M">M. Reiter</name></author><author><name sortKey="Tauer, C" uniqKey="Tauer C">C. Tauer</name></author><author><name sortKey="Mundt, W" uniqKey="Mundt W">W. Mundt</name></author><author><name sortKey="Barrett, P N" uniqKey="Barrett P">P.N. Barrett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sridhar, P" uniqKey="Sridhar P">P. Sridhar</name></author><author><name sortKey="Awasthi, A K" uniqKey="Awasthi A">A.K. Awasthi</name></author><author><name sortKey="Azim, C A" uniqKey="Azim C">C.A. Azim</name></author><author><name sortKey="Burma, S" uniqKey="Burma S">S. Burma</name></author><author><name sortKey="Habib, S" uniqKey="Habib S">S. Habib</name></author><author><name sortKey="Jain, A" uniqKey="Jain A">A. Jain</name></author><author><name sortKey="Mukherjee, B" uniqKey="Mukherjee B">B. Mukherjee</name></author><author><name sortKey="Ranjan, A" uniqKey="Ranjan A">A. Ranjan</name></author><author><name sortKey="Hashain, S E" uniqKey="Hashain S">S.E. Hashain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, Y J" uniqKey="Tan Y">Y.J. Tan</name></author><author><name sortKey="Goh, P Y" uniqKey="Goh P">P.Y. Goh</name></author><author><name sortKey="Fielding, B C" uniqKey="Fielding B">B.C. Fielding</name></author><author><name sortKey="Shen, S" uniqKey="Shen S">S. Shen</name></author><author><name sortKey="Chou, C F" uniqKey="Chou C">C.F. Chou</name></author><author><name sortKey="Fu, J L" uniqKey="Fu J">J.L. Fu</name></author><author><name sortKey="Leong, H N" uniqKey="Leong H">H.N. Leong</name></author><author><name sortKey="Leo, Y S" uniqKey="Leo Y">Y.S. Leo</name></author><author><name sortKey="Ooi, E E" uniqKey="Ooi E">E.E. Ooi</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A.E. Ling</name></author><author><name sortKey="Lim, S G" uniqKey="Lim S">S.G. Lim</name></author><author><name sortKey="Hong, W" uniqKey="Hong W">W. Hong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tjia, S T" uniqKey="Tjia S">S.T. Tjia</name></author><author><name sortKey="Zu Altenschildesche, G M" uniqKey="Zu Altenschildesche G">G.M. zu Altenschildesche</name></author><author><name sortKey="Doerfler, W" uniqKey="Doerfler W">W. Doerfler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Volkman, L E" uniqKey="Volkman L">L.E. Volkman</name></author><author><name sortKey="Goldsmith, P A" uniqKey="Goldsmith P">P.A. Goldsmith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name></author><author><name sortKey="Chou, T H" uniqKey="Chou T">T.H. Chou</name></author><author><name sortKey="Sakhatskyy, P V" uniqKey="Sakhatskyy P">P.V. Sakhatskyy</name></author><author><name sortKey="Huang, S" uniqKey="Huang S">S. Huang</name></author><author><name sortKey="Lawrence, J M" uniqKey="Lawrence J">J.M. Lawrence</name></author><author><name sortKey="Cao, H" uniqKey="Cao H">H. Cao</name></author><author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name></author><author><name sortKey="Lu, S" uniqKey="Lu S">S. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B.H. Wong</name></author><author><name sortKey="Tsoi, H W" uniqKey="Tsoi H">H.W. Tsoi</name></author><author><name sortKey="Fung, A M" uniqKey="Fung A">A.M. Fung</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Tam, V K" uniqKey="Tam V">V.K. Tam</name></author><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, P C" uniqKey="Woo P">P.C. Woo</name></author><author><name sortKey="Lau, S K" uniqKey="Lau S">S.K. Lau</name></author><author><name sortKey="Tsoi, H W" uniqKey="Tsoi H">H.W. Tsoi</name></author><author><name sortKey="Chen, Z W" uniqKey="Chen Z">Z.W. Chen</name></author><author><name sortKey="Wong, B H" uniqKey="Wong B">B.H. Wong</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L. Zhang</name></author><author><name sortKey="Chan, J K" uniqKey="Chan J">J.K. Chan</name></author><author><name sortKey="Wong, L P" uniqKey="Wong L">L.P. Wong</name></author><author><name sortKey="He, W" uniqKey="He W">W. He</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C. Ma</name></author><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Ho, D D" uniqKey="Ho D">D.D. Ho</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.Y. Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, C Y" uniqKey="Wu C">C.Y. Wu</name></author><author><name sortKey="Kirman, J R" uniqKey="Kirman J">J.R. Kirman</name></author><author><name sortKey="Rotte, M J" uniqKey="Rotte M">M.J. Rotte</name></author><author><name sortKey="Davey, D F" uniqKey="Davey D">D.F. Davey</name></author><author><name sortKey="Perfetto, S P" uniqKey="Perfetto S">S.P. Perfetto</name></author><author><name sortKey="Rhee, E G" uniqKey="Rhee E">E.G. Rhee</name></author><author><name sortKey="Freidag, B L" uniqKey="Freidag B">B.L. Freidag</name></author><author><name sortKey="Hill, B J" uniqKey="Hill B">B.J. Hill</name></author><author><name sortKey="Douek, D C" uniqKey="Douek D">D.C. Douek</name></author><author><name sortKey="Seder, R A" uniqKey="Seder R">R.A. Seder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Z Y" uniqKey="Yang Z">Z.Y. Yang</name></author><author><name sortKey="Kong, W P" uniqKey="Kong W">W.P. Kong</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y. Huang</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A. Roberts</name></author><author><name sortKey="Murphy, B R" uniqKey="Murphy B">B.R. Murphy</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K. Subbarao</name></author><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zakhartchouk, A N" uniqKey="Zakhartchouk A">A.N. Zakhartchouk</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q. Liu</name></author><author><name sortKey="Petric, M" uniqKey="Petric M">M. Petric</name></author><author><name sortKey="Babiuk, L A" uniqKey="Babiuk L">L.A. Babiuk</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Bai, Bingke" sort="Bai, Bingke" uniqKey="Bai B" first="Bingke" last="Bai">Bingke Bai</name></noRegion><name sortKey="Bai, Bingke" sort="Bai, Bingke" uniqKey="Bai B" first="Bingke" last="Bai">Bingke Bai</name><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name><name sortKey="Hu, Qinxue" sort="Hu, Qinxue" uniqKey="Hu Q" first="Qinxue" last="Hu">Qinxue Hu</name><name sortKey="Lu, Baojing" sort="Lu, Baojing" uniqKey="Lu B" first="Baojing" last="Lu">Baojing Lu</name><name sortKey="Lu, Baojing" sort="Lu, Baojing" uniqKey="Lu B" first="Baojing" last="Lu">Baojing Lu</name><name sortKey="Lu, Xinya" sort="Lu, Xinya" uniqKey="Lu X" first="Xinya" last="Lu">Xinya Lu</name><name sortKey="Lu, Xinya" sort="Lu, Xinya" uniqKey="Lu X" first="Xinya" last="Lu">Xinya Lu</name><name sortKey="Mao, Panyong" sort="Mao, Panyong" uniqKey="Mao P" first="Panyong" last="Mao">Panyong Mao</name><name sortKey="Meng, Jin" sort="Meng, Jin" uniqKey="Meng J" first="Jin" last="Meng">Jin Meng</name><name sortKey="Meng, Jin" sort="Meng, Jin" uniqKey="Meng J" first="Jin" last="Meng">Jin Meng</name><name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name><name sortKey="Yuan, Zhiming" sort="Yuan, Zhiming" uniqKey="Yuan Z" first="Zhiming" last="Yuan">Zhiming Yuan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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